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Unfortunately, the direct use protein neurotrophic factors as therapeutic agents has at least two serious limitations: 1 ) their large size and hydrophilic character preclude blood- brain barrier permeability (BBB)

POPs are mainly excreted through conjugation with GSH and this mechanism is extremely important for the health status, since exposure to POPs has been associated to diabetes, cardiovascular diseases and many other chronic diseases (1, 13)

Gluten-Free diet in children with autism spectrum disorders: a randomized, controlled, single-blinded trial